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archerdan
A recent observation has caused me great concern. I enjoy watching the National Geographic and Science Channels to relax. I watched 2 programs within a 2 week period that gave conflicting information on the disease that decimated Native American populations around the time of Cortez.

The first, was new evidence that it was a Hantavirus that was the guilty disease. Linking the affects of the disease, severe bleeding from mouth, mucus membranes etc., to known diseases from Europe at the time didn't pan out. There is no evidence to support this claim that has been taught in our schools since I was a child. The disease description matched the affects of Hantavirus. After studying the break out of this deadly disease in 1992 and 1993, near where I lived in the South West, the mice responsible for this outbreak were associated with weather patterns of abundant rain following a drought. Tree ring dating matched these conditions to the area where Cortez interacted with the Native Americans. The infected rodent population in proximity with people and food, following this extended drought, put these populations at grave risk. In the more recent outbreak in the South West U.S., the center for disease control quickly identified the infected mice and were able to neutralize them, preventing the spread of Hantavirus.

The second program that addressed the issue was about viruses, and gave the old information we have received since our youth in our public schools. It blamed the epidemic on Smallpox, while the evidence we have for that epidemic does not support this. Latter, smallpox WAS introduced into native population, in U.S. and it's territories, by what is believed to have been, contaminated trade blankets. No mention was made of the hantavirus in this program.

The danger of misinformation is this. After extended drought from Laninio, the South Western U.S. is once more entering into Laninia, a period of higher than average rain fall that has been tied to this pattern of hantavirus. The populations of these areas are unaware of the health risk,
and are not taking the necessary precautions. The last time this disease outbreak was mostly isolated in a remote region of reservation. The out break was in the 4 Corners Area of the U.S.
Colorado, Utah, New Mexico, and Arizona. After a relatively quiet period, much of the U.S., including the South West, is beginning to change the weather pattern from drought to above average rain fall. Deaths from hantavirus have already begun to be identified, 4 that I know of in Colorado in 2007, and 2 more in Wyoming in 2008. As we are just starting the full scale transition into Laninia, There is time to take necessary precautions to be prepared for the resulting explosion in rodent populations. The hantavirus is here, but rodent populations are the key.

Education has always been our best defense against disease. There is no treatment for this killer.
I believe the Myan epidemic resulted in up to 80% population reduction of the affected area.

Here is a helpful link.
http://www.esa.org/education_diversity/pdf.../hantavirus.pdf

Dan
DuzmA
http://www.cdc.gov/ncidod/EID/vol10no12/04-0684.htm


^-- Not exactly on key but very interesting.
archerdan
DuzmA,

Thank you for the link.

"We could not show that vaccine effectiveness estimates were significant. All of our confidence intervals have lower bounds less than zero. Therefore, while point estimates show effectiveness, this finding could be due to chance. Of course, the range of point estimates in studies with relatively small samples can be wide, and wide confidence intervals that include zero are not uncommon in many studies on vaccine effectiveness (9). However, caution is appropriate in interpreting our estimates of vaccine effectiveness.

Finally, this study represents a short-term (7.3 months average) evaluation of protective effectiveness of three doses of the hantavirus vaccine. To assess the long-term effectiveness, protection must be monitored over a longer period.

The authors do not have commercial or other associations that might pose a conflict of interest. In addition, this work had no financial support.

Dr. Park is an epidemiologist in the National Cancer Center, Goyang, Republic of Korea. His area of interest is the evaluation of preventive measures in public health area."


While this vaccine is of questionable value, that there is one at all is promising. At least in Korea,
someone realizes the epidemic potential and is working on the problem.

I would like to see a vaccine for the strains we have in the Americas as well, especially the new strain discovered in the 1992/93 outbreak in the 4 corners area. I am no expert, and wonder how affective even a proven vaccine for one strain of hantavirus will be on this new, different strain.
Like flu vaccines, will a change in the infecting virus be significant enough to prevent an otherwise affective vaccine from working?

Dan


DuzmA
QUOTE (archerdan+Feb 22 2009, 05:24 PM)
DuzmA,

Thank you for the link.

"We could not show that vaccine effectiveness estimates were significant. All of our confidence intervals have lower bounds less than zero. Therefore, while point estimates show effectiveness, this finding could be due to chance. Of course, the range of point estimates in studies with relatively small samples can be wide, and wide confidence intervals that include zero are not uncommon in many studies on vaccine effectiveness (9). However, caution is appropriate in interpreting our estimates of vaccine effectiveness.

Finally, this study represents a short-term (7.3 months average) evaluation of protective effectiveness of three doses of the hantavirus vaccine. To assess the long-term effectiveness, protection must be monitored over a longer period.

The authors do not have commercial or other associations that might pose a conflict of interest. In addition, this work had no financial support.

Dr. Park is an epidemiologist in the National Cancer Center, Goyang, Republic of Korea. His area of interest is the evaluation of preventive measures in public health area."


While this vaccine is of questionable value, that there is one at all is promising. At least in Korea,
someone realizes the epidemic potential and is working on the problem.

I would like to see a vaccine for the strains we have in the Americas as well, especially the new strain discovered in the 1992/93 outbreak in the 4 corners area. I am no expert, and wonder how affective even a proven vaccine for one strain of hantavirus will be on this new, different strain.
Like flu vaccines, will a change in the infecting virus be significant enough to prevent an otherwise affective vaccine from working?

Dan

Yes the point of the link was to show that there was concern about the issue, even if that concern wasn't in the US. I have done some more reading on the virus and it is a bit disconcerting. I don't see that there is much potential for hantavirus to reach epidemic status. Based on what I have read I would say that there is an extreme need for the education of people in the region about the dangers posed by the hantavirus, but vaccine production research might be better used elsewhere. What do you think?
archerdan
Duzma,

I agree that the hantavirus is not the Pandemic threat that Avian Influenza is. It is really a geographically isolated event, as I understand it. Education seems to be the best way to protect
against it. Even when rodent populations become extreme, it doesn't mean that there will be the right strain of hantavirus for an epidemic. However, if our new findings are correct, it has killed millions before, and the potential to kill millions again is still there.

What would be the best way to educate people?

If they are not aware of the devastation to native populations in the past, would they even take it seriously? Small Pox is gone. No worries. Something that is still here and active? Maybe worth looking into prevention.

Dan
archerdan
As with any virus, the concern is a strain mutating to be able to pass from human to human.

The CDC tells us that Hantavirus is not transmitted from human to human in the U.S.
However, after 2195 cases of hantavirus in Sweden in 2007, a closer look was taken at their strain of hantavirus. Tests show it is in human saliva.

http://www.sciencedaily.com/releases/2008/...80118093221.htm

The CDC website provides good information on prevention of hantavirus. AS long as
it doesn't make a human to human jump, the prevention steps outlined in the CDC website seem to be enough.

Dan
willson
A conflict of interest would be a criminalist working on the case of her cousin. She might make certain judgements or decisions that she would not make if the case did not involve her cousin. Does that make sense???

conflict of interest -
1. the circumstance of a public officeholder, business executive, or the like, whose personal interests might benefit from his or her official actions or influence: The senator placed his stocks in trust to avoid possible conflict of interest.
2. the circumstance of a person who finds that one of his or her activities, interests, etc., can be advanced only at the expense of another of them.

disclaimer -
1. the act of disclaiming; the renouncing, repudiating, or denying of a claim; disavowal.
2. a person who disclaims.
3. a statement, document, or assertion that disclaims responsibility, affiliation, etc.;
sporacle
Not to worry about hantavirus. There is detailed history of viral and bacterial disease epidemics over the past several centuries available, and there is a huge CDC database of what is happening lately, so don't go off and running before you check out the data.

The hantavirus is endemic in mice, but the only way to get it yourself is inhale lots of pulverized dust from mouse turds. The few reported cases were of people cleaning out places where the mice had taken over. Generally people don't chose to live in a herd of mice.

The measles and smallpox viruses were devastating to the Native American population when Columbus and crew and then others arrived. Native American people had little immunity to European Smallpox and Measles viruses.

A real concern now is flu viruses mutating and spreading quickly around the world by international travel of people. Duck, pig and people viruses mutate together wherever ducks, pigs and people live closely together, and it's fairly common.

spo

mdjww
Wow! I’ve never heard of this before and I think they’re awesome!
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