El_Machinae
27th September 2007 - 11:19 AM
I'm pretty proud of this one, because I was a bit worried that the system wasn't designed to test something like this.
There's a fairly cheap compound, that's already been proven acceptably-safe in people, that might be an effect cancer-killing drug. The problem was that the drug was cheap and common - meaning that no drug companies are willing to undergo the $800 million of running it through a clinical trial ... they'd never be able to patent it and profit off it.
Because it wasn't being run through a clinical trial, there was no way to 'prove' (within the system) that the compound is effective. People were selling the compound to treat "Pet cancers" (wink, wink) but those companies get shut down because people assume that they're selling to cancer victims who will self-dose without any medical supervision (because none is available yet)
It's marvelously effective in animals, but only about 2% of drugs which work in animals end up being effective in people.
Anyway, it looks like Canada Health has stepped up to the plate. We've approved a clinical trial of the compound. I'm crossing my fingers on this one.
http://www.expressnews.ualberta.ca/article.cfm?id=8760QUOTE
Health Canada has approved clinical trial of a promising new cancer treatment that will be tested on patients with one of the most aggressive forms of cancer.
Known commonly as DCA the drug, dichloroacetate, was proven to cause regression in several cancers, including lung, breast and brain tumours in mice and in human tissues in vitro. The research by cardiologist
...
Today, Michelakis told reporters that Health Canada has approved phase II clinical trials of the drug in patients diagnosed with a type of brain tumour called malignant gliomas. The mean survival rate for these patients is one year.
...
Michelakis and his colleagues at Capital Health are looking for 50 patients for the clinical trial. Patients interested in enrolling in the clinical trial should visit the DCA website or call 492-2604.[El_Mac note: apparently patients need to be local to Edmonton
...
Michelakis said that the fact that the clinical trials are being done at all is a miracle. The drug itself cannot be patented, so no pharmaceutical firm is funding the research. Instead, about $800,000 has been raised by donors from all over the world.
For those who want more detailed knowledge on the biochemistry, here's a link to a good podcast interview with the doctor
http://www.twit.tv/fib21NOTE TO ALL:
There is a lot of medical data out there for safe dosing levels for other diseases and a qualified and determined doctor should be able to piece together a dosing strategy. However, it is greatly recommended that people don't try this on their own - too few people are qualified to understand the biochemistry (to determine if it's appropriate to a specific cancer) and dosing levels. So, don't try this at home
adoucette
6th October 2007 - 02:17 PM
While developing a drug might cost a lot, the actual Clinical Trials don't cost anywhere near $800 MILLION.
Note this one was started for LESS than the $800,000 raised.
Finally, in this case, because the drug is already approved for human use, it can be prescibed by any doctor for any reason.
You don't have to wait for the clinical trial to complete, simply go to Medicor, show your Health card and get the drugs.
http://www.medicorcancer.ca/DCAtherapy.htmlThe DCA costs ~ $150/wk and medical costs approx the same.
Since I'm not Canadian, Medicor will charge me a bit more (but not that much since Health Canada won't pay for the DCA for Canadians either)
I've talked to them and my wife's oncologist and they suggest continuing with the clinical trial she is in until/if it shows signs that it is not working, and then switch to DCA. I'd prefer to try both at the same time as the drugs have totally different pathways, and we may decide to do that anyway (the hell with the doctors, easy for them to say since they aren't the one who is dying).
Arthur
wcelliott
21st October 2007 - 08:25 AM
I'm glad to hear that Canada is taking this path.
Our approach to health care in this country is an embarrassment. Free enterprise is all well and good, but when peoples' lives are at stake, and pharmaceutical companies and the government both turn their backs because of profit and politics, it just reeks.
When people are dying, money and politics should take a back seat to saving their lives.
Unfortunately, the FDA takes a different stance. They shut down the DCA site, and are cracking-down on other alternative medicine sites, too. Funny, I see advertisements on TV for drugs that are supposed to make guys' genitals bigger, nobody is shutting them down, but somebody points out that cherries have been recently proved to prevent heart disease (true statement) and the FDA shuts down their site.
The FDA seems to be concentrating their efforts on alternate medicines that actually work.
Colloidal silver has been shown effective at killing MRSA, anthrax (it's what they used to decontaminate the Congressional offices exposed to anthrax in 2001), and the AIDS virus, and Parvo in dogs, plus many others, and the FDA is going after them, too. It'd be one thing if the FDA took it upon itself to only go after people making FALSE claims, I'd be all-in-favor of that, or if they shut-down sites selling drugs that are riskier or less-effective than conventional drugs, I could see that, too, but they're going after people selling drugs that work better than the conventional drugs for diseases that are considered "incurable".
Here's a thought - Maybe the FDA could take some of it's budget and do real tests to see if these "orphan drugs" (i.e., ones that Big Pharma aren't interested in selling) really work, and if they do, then they should just let the doctors prescribe them.
Incidentally, another cancer treatment that falls into that category is Intravenous Vitamin C. Vitamin C in doses too large to get from taking pills orally, like 25 - 75 grams, kills various common cancers while leaving normal human cells unaffected. If it was a chemotherapy agent that could be patented that worked that well, the Big Pharmaceutical manufacturers would be all over it, scrambling to get it to the market, but since they can't get a patent on Vitamin C, forget it!
Another is sodium nitrite, which in small doses (e.g., 5mg), taken during a stroke or heart attack, prevents ischemic damage from occurring to the tissues downstream of the blood clot, even when the blood flow's been cut off for hours. Sodium nitrite is in hot dogs to keep them from turning gray, we eat it all the time, but the FDA won't approve it for use in stroke and heart attack patients without $800million in safety/effectiveness research. The two leading causes of death, less than a penny's worth of drug could save hundreds of thousands of lives per year, and politics/profits are in the way. It's shameful.
I'm hoping that some presidential candidate will take this matter seriously enough to actually fix the problem. We've got cures for cancer, AIDS, heart attacks, strokes, maybe even Ebola (Colloidal Silver works against all viruses the same way), and people are still dying from them becuase the system's screwed-up.
I hope America follows Canada's lead.
joshjoihn
16th December 2008 - 07:04 PM
Here you can find observation data gathered by Canadian Clinic - Medicor Cancer
Centres durning DCA therapy:
medicorcancer.com/DCAtherapyData.html
and here are 4 cases treated with DCA:
forums.cancer.vc/respiratory-thoracic/158-case-study-1-mesothelioma-new-post.html
forums.cancer.vc/skin/157-case-study-2-melanoma-brain-metastases-new-post.html
medicorcancer.com/DCA-CaseStudy3.html
medicorcancer.com/DCA-CaseStudy4.html
here's an lymphoma remission story using DCA B1 vitamine protocol:
forums.cancer.vc/hematologic-blood/54-ds-lymphoma-story.html
and here are other remissions:
forums.cancer.vc/hematologic-blood/62-case-non-hodgkins-lymphoma-apparent-complete-remission.html
forums.cancer.vc/genitourinary-cancer/48-wim-huppes-prostate-cancer-story.html
forums.cancer.vc/genitourinary-cancer/55-ps-kidney-cancer-story.html
forums.cancer.vc/lung-cancer/56-tom-mcghees-nearly-full-remission-non-small-cell-lung-cancer.html
forums.cancer.vc/lung-cancer/63-lung-cancer-remission-dca.html
forums.cancer.vc/digestive-gastrointestinal/47-colo-rectal-cancer-story.html
forums.cancer.vc/digestive-gastrointestinal/57-bills-bile-duct-cancer-story.html
forums.cancer.vc/digestive-gastrointestinal/81-gastro-intestinal-stromal-tumors-dca.html
for more info on alternative therapies and dca see forums.cancer.vc